Eslicarbazepine Acetate and Simvastatin Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Eslicarbazepine may reduce the blood levels and effects of simvastatin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with eslicarbazepine acetate may decrease the plasma concentrations of simvastatin. The proposed mechanism is eslicarbazepine induction of the CYP450 3A4-mediated metabolism of simvastatin. In healthy study subjects, simvastatin systemic exposure (AUC) decreased by an average of 50% when coadministered with eslicarbazepine acetate 800 mg once daily.

MANAGEMENT: The potential for diminished therapeutic effects of simvastatin should be considered when prescribed in combination with eslicarbazepine acetate. A dosage increase for simvastatin may be required based on efficacy and tolerability.

Eslicarbazepine Acetate

Generic Name: eslicarbazepine

Brand name: Aptiom

Synonyms: Eslicarbazepine

What is Eslicarbazepine Acetate?

Simvastatin Tablets

Generic Name: simvastatin

Brand name: Zocor, Flolipid

Synonyms: Simvastatin

What is Simvastatin Tablets?