Esomeprazole and naproxen and Valproic acid
Determining the interaction of Esomeprazole and naproxen and Valproic acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using naproxen together with esomeprazole. Using these medications together may affect the enteric coating of naproxen, causing the medication to be released too early in the body. This can make naproxen less effective. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Theoretically, proton pump inhibitors may decrease the gastrointestinal absorption of enteric-coated naproxen, which requires an acidic environment for dissolution. The proposed mechanism is an increase in gastric pH (i.e. decreased gastric acidity) induced by proton pump inhibitors. In patients treated with proton pump inhibitors, the possibility of a reduced or subtherapeutic response to enteric-coated naproxen should be considered.
MANAGEMENT: Concomitant use of these drugs is generally not recommended.
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
Generic Name: esomeprazole / naproxen
Brand name: Vimovo
Synonyms: Naproxen and Esomeprazole
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic Acid and Derivatives
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Esomeprazole and naproxen-Valproic Acid and Derivatives
- Esomeprazole and naproxen-Valproic Acid Capsules
- Esomeprazole and naproxen-Valproic Acid Liquid
- Esomeprazole and naproxen-Valproic Acid Oral Solution
- Esomeprazole and naproxen-Valproic Acid Syrup
- Esomeprazole and naproxen-Valrubicin
- Valproic acid-Esomeprazole Capsules
- Valproic acid-Esomeprazole Delayed-Release Capsules
- Valproic acid-Esomeprazole Delayed-Release Tablets
- Valproic acid-Esomeprazole injection
- Valproic acid-Esomeprazole Magnesium
- Valproic acid-Esomeprazole Oral, Intravenous