Esomeprazole Powder for Suspension and Pioglitazone and Glimepiride Tablets
Determining the interaction of Esomeprazole Powder for Suspension and Pioglitazone and Glimepiride Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some benzimidazole proton pump inhibitors may increase sulfonylurea concentrations, and hypoglycemic effects may be increased. The mechanism may be inhibition of CYP450 2C19 and/or 3A4 hepatic metabolism. The clinical significance of this interaction is unknown. Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients.
- Toon S, Holt BL, Mullins FGP, Khan A "Effects of cimetidine, ranitidine and omeprazole on tolbutamide pharmacokinetics." J Pharm Pharmacol 47 (1995): 85-8
- Humphries TJ "Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole." Dig Dis Sci 36 (1991): 1665-9
- "Product Information. Nexium (esomeprazole)" Astra-Zeneca Pharmaceuticals, Wilmington, DE.
- "Product Information. Prilosec (omeprazole)." Merck & Co, Inc, West Point, PA.
Generic Name: esomeprazole
Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: Esomeprazole
Generic Name: glimepiride / pioglitazone
Brand name: Duetact
Synonyms: Glimepiride and pioglitazone, Pioglitazone and Glimepiride
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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