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Esomeprazole Strontium and Nelfinavir Mesylate

Determining the interaction of Esomeprazole Strontium and Nelfinavir Mesylate and the possibility of their joint administration.

Check result:

Esomeprazole Strontium <> Nelfinavir Mesylate

Relevance: 06.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using nelfinavir together with esomeprazole is not recommended. By reducing stomach acid, esomeprazole can decrease the absorption and blood levels of nelfinavir and make the medication less effective against HIV. Your doctor or pharmacist may be able to offer suggestions on safer alternatives if you require treatment for stomach acid or ulcer while you are being treated with nelfinavir. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concurrent use of proton pump inhibitors may decrease the oral bioavailability of nelfinavir and reduce its concentrations in plasma. Nelfinavir solubility may decrease with increasing pH, thus inhibition of gastric acid secretion may interfere with dissolution of the drug. In one study, administration of omeprazole (40 mg once daily) 30 minutes before nelfinavir (1250 mg twice a day) for 4 days reduced the peak plasma concentration, trough plasma concentration, and systemic exposure (AUC) of nelfinavir by a little over one-third.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, use of proton pump inhibitors is not recommended in patients treated with nelfinavir.

References

"Product Information. Viracept (nelfinavir)." Agouron Pharma Inc, La Jolla, CA.
Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9

Esomeprazole Strontium

Generic Name: esomeprazole

Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Synonyms: Esomeprazole

What is Esomeprazole Strontium?

Nelfinavir Mesylate

Generic Name: nelfinavir

Brand name: Viracept

Synonyms: Nelfinavir

What is Nelfinavir Mesylate?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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