Esomeprazole Strontium and Tipranavir Oral Solution
Determining the interaction of Esomeprazole Strontium and Tipranavir Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Tipranavir can decrease the levels of esomeprazole in your body. You may need a dose adjustment if you have been taking esomeprazole and are starting treatment with tipranavir. Let your doctor know if esomeprazole becomes less effective or is no longer controlling your symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: The concomitant administration of tipranavir-ritonavir with omeprazole or esomeprazole may significantly decrease systemic exposure to the proton pump inhibitors. The proposed mechanism is induction of CYP450 2C19 metabolism by tipranavir-ritonavir. In clinical studies, concurrent administration of tipranavir-ritonavir reduced the steady state AUC and Cmax of omeprazole by 71% and 73%, respectively. Esomeprazole, the S-enantiomer of omeprazole, was similarly affected.
MANAGEMENT: If this combination is given concurrently, patients should be monitored for altered clinical efficacy of the proton pump inhibitor. Dose adjustments may be necessary; however, specific dosage recommendations are not available.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- "Product Information. Aptivus (tipranavir)." Boehringer-Ingelheim, Ridgefield, CT.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: esomeprazole
Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV
Synonyms: Esomeprazole
Generic Name: tipranavir
Brand name: Aptivus
Synonyms: Tipranavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Esomeprazole Strontium-Tirofiban
- Esomeprazole Strontium-Tirofiban Intravenous
- Esomeprazole Strontium-Tirosint
- Esomeprazole Strontium-Tirosint-Sol
- Esomeprazole Strontium-Tisagenlecleucel
- Esomeprazole Strontium-Tisagenlecleucel Intravenous
- Tipranavir Oral Solution-Essian
- Tipranavir Oral Solution-Essian H.S.
- Tipranavir Oral Solution-Estalis
- Tipranavir Oral Solution-Estalis-Sequi
- Tipranavir Oral Solution-Estar Topical
- Tipranavir Oral Solution-Estarylla