Estradiol and Dienogest and Welchol (Colesevelam Oral Suspension)
Determining the interaction of Estradiol and Dienogest and Welchol (Colesevelam Oral Suspension) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using colesevelam together with dienogest may decrease the effects of dienogest. Dienogest should be administered at least 4 hours before colesevelam. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Colesevelam may decrease the gastrointestinal absorption of contraceptive hormones. A 24% reduction in peak plasma concentration (Cmax) and systemic exposure (AUC) has been reported for ethinyl estradiol (0.035 mg), and a 20% reduction in Cmax has been reported for norethindrone (1 mg).
MANAGEMENT: Oral contraceptives containing ethinyl estradiol and norethindrone should be administered at least 4 hours before the colesevelam dose. The same precaution may be applicable to other contraceptive hormones, although data are lacking.
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: dienogest / estradiol
Brand name: Natazia
Synonyms: Dienogest and estradiol
Generic Name: colesevelam
Brand name: Welchol, Colesevelam Hydrochloride
Synonyms: Welchol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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