Estradiol and norgestimate and Indinavir Sulfate
Determining the interaction of Estradiol and norgestimate and Indinavir Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with indinavir may increase the plasma concentrations of estrogens and progestins. The proposed mechanism is indinavir inhibition of CYP450 3A4, the isoenzyme involved in the metabolism of estrogens, some (if not all) progestins, and other steroids. According to product labeling, indinavir (800 mg every 8 hours) increased the area under the plasma concentration-time curve (AUC) of ethinyl estradiol and norethindrone (administered as Ortho-Novum 1/35 once daily) by approximately 25% each after one week. The clinical significance of these alterations is unknown but should be considered when selecting oral contraceptive and hormone replacement doses.
- "Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
Generic Name: estradiol / norgestimate
Brand name: Prefest, Ortho-Prefest
Synonyms: Estradiol and Norgestimate
Generic Name: indinavir
Brand name: Crixivan
Synonyms: Indinavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Indinavir Sulfate-Estradiol Gel (EstroGel)
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