Estradiol Gel (Divigel) and Fentanyl Lozenge
Determining the interaction of Estradiol Gel (Divigel) and Fentanyl Lozenge and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration of fentanyl with other drugs, such as estrogens, that are also metabolized by CYP450 may theoretically result in elevated plasma concentrations of fentanyl and/or the coadministered drug(s). The mechanism is decreased drug clearance due to competitive inhibition of CYP450 activity. Although clinical data are lacking, the possibility of prolonged and/or increased pharmacologic effects of the drugs should be considered.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: estradiol
Brand name: Estrace, Vivelle-Dot, Vivelle, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estraderm, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Climara, Estradiol Patch, Depo-Estradiol, Elestrin Pump, EstroGel Pump, Femring, Gynodiol
Synonyms: Estradiol, Estradiol (Systemic)
Generic Name: fentanyl
Brand name: Duragesic, Abstral, Fentora, Subsys, Actiq, Ionsys, Lazanda, Onsolis, Sublimaze
Synonyms: Fentanyl Patch, FentaNYL
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Estradiol Gel (Divigel)-Fentanyl nasal
- Estradiol Gel (Divigel)-Fentanyl Nasal Spray
- Estradiol Gel (Divigel)-Fentanyl Novaplus Patch
- Estradiol Gel (Divigel)-Fentanyl Sublingual Spray
- Estradiol Gel (Divigel)-Fentanyl Sublingual Tablet
- Estradiol Gel (Divigel)-Fentanyl Transdermal
- Fentanyl Lozenge-Estradiol Gel (Elestrin)
- Fentanyl Lozenge-Estradiol Gel (EstroGel)
- Fentanyl Lozenge-Estradiol injection
- Fentanyl Lozenge-Estradiol Oral Tablets
- Fentanyl Lozenge-Estradiol Patch
- Fentanyl Lozenge-Estradiol topical for use on skin