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Estradiol (Systemic) and Subsys

Determining the interaction of Estradiol (Systemic) and Subsys and the possibility of their joint administration.

Check result:

Estradiol (Systemic) <> Subsys

Relevance: 01.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration of fentanyl with other drugs, such as estrogens, that are also metabolized by CYP450 may theoretically result in elevated plasma concentrations of fentanyl and/or the coadministered drug(s). The mechanism is decreased drug clearance due to competitive inhibition of CYP450 activity. Although clinical data are lacking, the possibility of prolonged and/or increased pharmacologic effects of the drugs should be considered.

References

Cerner Multum, Inc. "Australian Product Information." O 0

Estradiol (Systemic)

Generic Name: estradiol

Brand name: Estrace, Vivelle-Dot, Vivelle, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estraderm, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Climara, Estradiol Patch, Depo-Estradiol, Elestrin Pump, EstroGel Pump, Femring, Gynodiol

Synonyms: Estradiol

What is Estradiol (Systemic)?

Subsys

Generic Name: fentanyl

Brand name: Abstral, Fentora, Subsys, Actiq, Duragesic, Ionsys, Lazanda, Onsolis, Sublimaze

Synonyms: n.a.

What is Subsys?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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