Estradiol Transdermal Spray and Mifeprex
Determining the interaction of Estradiol Transdermal Spray and Mifeprex and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:MiFEPRIStone may increase the blood levels and effects of estradiol, even after you have stopped taking miFEPRIStone for a while. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro inhibition data, coadministration with mifepristone may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by mifepristone.
MANAGEMENT: Caution is advised if mifepristone must be used concomitantly with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever mifepristone is added to or withdrawn from therapy. Because mifepristone is eliminated slowly from the body, drug interactions may be observed for a prolonged period following discontinuation (approximately 2 to 3 weeks if mifepristone had been administered chronically to steady state).
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7
- "Product Information. Mifeprex (mifepristone)" Danco Laboratories, New York, NY.
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: estradiol
Brand name: Estrace, Vivelle-Dot, Vivelle, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estraderm, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Climara, Estradiol Patch, Depo-Estradiol, Elestrin Pump, EstroGel Pump, Femring, Gynodiol
Synonyms: Estradiol, Estradiol (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Estradiol Transdermal Spray-Mifepristone
- Estradiol Transdermal Spray-Mifepristone Tablets
- Estradiol Transdermal Spray-Mifepristone Tablets (For Ending Early Pregnancy)
- Estradiol Transdermal Spray-Mifepristone Tablets (For High Blood Sugar)
- Estradiol Transdermal Spray-Migalastat
- Estradiol Transdermal Spray-Migalastat Hydrochloride
- Mifeprex-Estradiol Transdermal Weekly Patch
- Mifeprex-Estradiol Transdermal Weekly Patch (Osteoporosis)
- Mifeprex-Estradiol vaginal
- Mifeprex-Estradiol Vaginal Cream
- Mifeprex-Estradiol Vaginal Insert
- Mifeprex-Estradiol vaginal local