Estradiol Vaginal Ring (Estring) and Metopirone
Determining the interaction of Estradiol Vaginal Ring (Estring) and Metopirone and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using estradiol topical together with metyraPONE can interfere with metyraPONE. You should be aware of the possibility of a diagnostic interference if you use both medications. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor
Professional:MONITOR: Estrogen therapy may reduce the response to metyrapone test. The mechanism is related to an increase in serum cortisol-binding globulin (transcortin) induced by estrogens, resulting in decreased cortisol clearance. The increase in circulating cortisol may directly interfere with test results, since the pharmacologic effect of metyrapone is to inhibit adrenal production of cortisol and corticosterone in order to elicit an increase in ACTH production by the pituitary.
MANAGEMENT: Clinicians should recognize the potential for a diminished response to metyrapone test in patients treated with estrogens.
- "Product Information. Femhrt (ethinyl estradiol-norethindrone)" Parke-Davis, Morris Plains, NJ.
Generic Name: estradiol topical
Brand name: Estrace Vaginal, Estring, Vagifem, Yuvafem, Imvexxy
Synonyms: Estradiol vaginal (local), Estradiol (Topical)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Estradiol Vaginal Ring (Estring)-Metoprolol
- Estradiol Vaginal Ring (Estring)-Metoprolol and hydrochlorothiazide
- Estradiol Vaginal Ring (Estring)-Metoprolol and Hydrochlorothiazide Extended-Release Tablets
- Estradiol Vaginal Ring (Estring)-Metoprolol and Hydrochlorothiazide Tablets
- Estradiol Vaginal Ring (Estring)-Metoprolol Extended-Release Capsules
- Estradiol Vaginal Ring (Estring)-Metoprolol Extended-Release Tablets
- Metopirone-Estradiol Vaginal Ring (Femring)
- Metopirone-Estradiol Vaginal Tablets
- Metopirone-Estradiol Valerate Injection
- Metopirone-Estradot Transdermal Therapeutic System Transdermal
- Metopirone-Estradot Transdermal Transdermal
- Metopirone-Estramustine