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Estradiol Valerate Injection and Kaletra

Determining the interaction of Estradiol Valerate Injection and Kaletra and the possibility of their joint administration.

Check result:

Estradiol Valerate Injection <> Kaletra

Relevance: 05.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ritonavir may reduce the blood levels and effects of estradiol. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of conjugated estrogens with ritonavir or nelfinavir may lead to decreased plasma concentrations of conjugated estrogens. The proposed mechanism may involve induction of the CYP450 3A4-mediated metabolism of conjugated estrogens by ritonavir and nelfinavir. Increased metabolism of estrogens may lead to decreased efficacy of the hormone replacement therapy. Ritonavir is a known CYP450 3A4 substrate and inhibitor; however, it has also been shown to reduce plasma concentrations of contraceptive hormones via a possible mechanism involving induction of glucuronosyltransferase and/or CYP450 hydroxylation. In addition, along with being a strong CYP450 3A4 inhibitor, nelfinavir has also been shown to possess CYP450 3A4-inducing properties.

MANAGEMENT: Dosage adjustments as well as increased clinical and laboratory monitoring should be considered whenever ritonavir or nelfinavir is added to or withdrawn from therapy with conjugated estrogens.

References

Dixit V, Hariparsad N, Li F, Desai P, Thummel KE, Unadkat JD "Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions." Drug Metab Dispos 35 (2007): 1853-9
Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception. Available from: URL: file:///C:/Users/df033684/Downloads/ceuguidancedruginteractionshormonal.pdf." ([2012, Jan 1]):
Ouellet D, Qian J, Locke CS, Eason CJ, Cavanaugh JH "Effect of ritonavir on the pharmacokinetics of ethinyl oestradiol in healthy female volunteers." Br J Clin Pharmacol 46 (1998): 111-6
"Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Estradiol Valerate Injection

Generic Name: estradiol

Brand name: Estrace, Vivelle-Dot, Vivelle, Delestrogen, DepoEstradiol, Divigel, Elestrin, Alora, Estraderm, Estradot, Estrasorb, Estrogel, Evamist, Femtrace, Menostar, Minivelle, Climara, Estradiol Patch, Depo-Estradiol, Elestrin Pump, EstroGel Pump, Femring, Gynodiol

Synonyms: Estradiol, Estradiol (Systemic)

What is Estradiol Valerate Injection?

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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