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Estramustine and Prestalia

Determining the interaction of Estramustine and Prestalia and the possibility of their joint administration.

Check result:

Estramustine <> Prestalia

Relevance: 08.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using estramustine together with perindopril may cause angioedema, a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet. Each medication alone can also cause angioedema, but the risk may be increased when they are combined. Angioedema can occur with the first dose of medication or after many doses. You should discontinue the medications and seek immediate medical attention if you develop symptoms of angioedema or have difficulty swallowing or breathing. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The concomitant administration of estramustine and angiotensin enzyme converting (ACE) inhibitors may increase the risk of angioedema. The mechanism is unknown. Cases of angioedema have been associated with estramustine administration; many of these patients were also receiving ACE inhibitors.

MANAGEMENT: It is recommended to monitor patients for adverse reactions during concomitant therapy. Clinicians and patients should be aware of the potential for increased risk of angioedema when estramustine is prescribed with ACE inhibitors. Patients should be advised to promptly discontinue these medications and seek medical attention if they develop signs or symptoms suggestive of angioedema such as swelling of the face, extremities, eyes, lips, or tongue, and difficulty swallowing or breathing.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Estramustine

Generic Name: estramustine

Brand name: Emcyt

Synonyms: n.a.

What is Estramustine?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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