Estrasorb and Tipiracil and trifluridine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using estradiol together with tipiracil may decrease the effectiveness of estradiol. If you are using low-dose oral contraceptives you may have an increased risk of breakthrough bleeding and unintended pregnancy. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with tipiracil-trifluridine may reduce the efficacy of contraceptive hormones. The mechanism has not been established. Trifluridine is an antineoplastic agent and may cause fetal harm when administered during pregnancy. Data evaluating the interaction are not available.

MANAGEMENT: Because trifluridine may cause fetal harm, it is particularly important that patients not become pregnant during tipiracil-trifluridine treatment. Female patients of childbearing potential using hormonal contraceptives should be advised of the risk of breakthrough bleeding and unintended pregnancy during concomitant tipiracil-trifluridine treatment. The manufacturer recommends use of additional barrier contraceptive methods during and for up to 6 months after tipiracil-trifluridine therapy. No recommendations are available for women using hormone-release intrauterine systems or injectable progestin-only contraceptives. Input from a gynecologist or similar expert on adequate contraception, including emergency contraception, should be sought as needed.

Estrasorb

Generic Name: estradiol

Brand name: Divigel, Elestrin Pump, Estrasorb, EstroGel Pump, Evamist, Alora, Climara, Estradiol Patch, Menostar, Minivelle, Vivelle-Dot, Estraderm, Vivelle, Delestrogen, Depo-Estradiol, Estrace, DepoEstradiol, Elestrin, Estradot, Estrogel, Femtrace, Femring, Gynodiol

Synonyms: n.a.

What is Estrasorb?

Tipiracil and trifluridine

Generic Name: tipiracil / trifluridine

Brand name: Lonsurf

Synonyms: Trifluridine and Tipiracil

What is Tipiracil and trifluridine?