Estring Vaginal Ring and Migalastat Hydrochloride

• Generic Name: estradiol topical
• Dosage Forms: n.a.
• Other Brand Names: Estrace Vaginal, Estring, Vagifem, Yuvafem, Imvexxy

Estring vaginal rings contain estradiol. Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the body. Estring releases estrogen that is absorbed directly through the skin of the vaginal wall.

Estring is used after menopause to treat moderate to severe menopausal changes in and around the vaginal area such as as dryness, burning, and itching of the vaginal area, urgency or irritation with urination, and pain during sexual intercourse).

Estring is an off-white, soft, flexible ring with a center that contains 2 mg of estradiol. The ring releases estradiol into the vagina in a consistent, stable manner for 90 days. It should be removed after 90 days of continuous use. If continued therapy is required, the ring should be replaced.

• Generic Name: migalastat
• Dosage Forms: n.a.
• Other Brand Names: Galafold

Migalastat hydrochloride is an alpha-galactosidase A (alpha-Gal A) pharmacological chaperone indicated for the treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene (GLA) variant based on in vitro assay data.

This indication is approved under accelerated approval based on reduction in kidney interstitial capillary cell globotriaosylceramide (KIC GL-3) substrate. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.