Ethacrynate Sodium and Naratriptan

• Generic Name: ethacrynic acid
• Dosage Forms: n.a.
• Other Brand Names: Edecrin, Edecrin Sodium, Sodium Edecrin

Management of edema associated with heart failure, hepatic cirrhosis, and renal disease (e.g., nephrotic syndrome).

Considered a diuretic of choice for most patients with heart failure.

Most experts state that all patients with symptomatic heart failure who have evidence for, or a history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction, an agent to inhibit the renin-angiotensin-aldosterone (RAA) system (e.g., ACE inhibitor, angiotensin II receptor antagonist, angiotensin receptor-neprilysin inhibitor [ARNI]), a β-adrenergic blocking agent (β-blocker), and in selected patients, an aldosterone antagonist.

Short-term management of ascites associated with malignancy, idiopathic edema, or lymphedema.

Short-term management of hospitalized pediatric patients, other than infants, with congenital heart disease or nephrotic syndrome. (See Pediatric Use under Cautions.)

IV ethacrynate sodium is used when rapid onset of diuresis is needed (e.g., acute pulmonary edema).

Has been used in the management of hypertension. However, not a recommended agent in current hypertension management guidelines.

May still be considered when diuretic therapy is indicated in patients hypersensitive to sulfonamides (e.g., other loop diuretics, thiazides) because ethacrynic acid is not a sulfonamide.

IV ethacrynate sodium has been used as an adjunct to hypotensive agents in the management of hypertensive crisis, especially when accompanied by pulmonary edema.

IV ethacrynate sodium has been used in the management of hypercalcemia, alone or with sodium chloride 0.9% injection.

Has been used with mannitol in the management of ethylene glycol poisoning.

Management of bromide intoxication.

Treatment of nephrogenic diabetes insipidus that is refractory to vasopressin or chlorpropamide.

• Generic Name: naratriptan
• Dosage Forms: n.a.
• Other Brand Names: Amerge

Naratriptan is a headache medicine that narrows blood vessels around the brain. Naratriptan also reduces substances in the body that can trigger headache pain, sensitivity to light and sound, and other migraine symptoms.

Naratriptan is used to treat migraine headaches. Naratriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Naratriptan should not be used to treat a common tension headache, a headache that causes loss of movement on one side of your body, or any headache that seems to be different from your usual migraine headaches. Use naratriptan only if your condition has been confirmed by a doctor as migraine headaches.

Naratriptan may also be used for purposes not listed in this medication guide.