Ethacrynate Sodium and Nexiclon XR Suspension

• Generic Name: ethacrynic acid
• Dosage Forms: n.a.
• Other Brand Names: Edecrin, Edecrin Sodium, Sodium Edecrin

Management of edema associated with heart failure, hepatic cirrhosis, and renal disease (e.g., nephrotic syndrome).

Considered a diuretic of choice for most patients with heart failure.

Most experts state that all patients with symptomatic heart failure who have evidence for, or a history of, fluid retention generally should receive diuretic therapy in conjunction with moderate sodium restriction, an agent to inhibit the renin-angiotensin-aldosterone (RAA) system (e.g., ACE inhibitor, angiotensin II receptor antagonist, angiotensin receptor-neprilysin inhibitor [ARNI]), a β-adrenergic blocking agent (β-blocker), and in selected patients, an aldosterone antagonist.

Short-term management of ascites associated with malignancy, idiopathic edema, or lymphedema.

Short-term management of hospitalized pediatric patients, other than infants, with congenital heart disease or nephrotic syndrome. (See Pediatric Use under Cautions.)

IV ethacrynate sodium is used when rapid onset of diuresis is needed (e.g., acute pulmonary edema).

Has been used in the management of hypertension. However, not a recommended agent in current hypertension management guidelines.

May still be considered when diuretic therapy is indicated in patients hypersensitive to sulfonamides (e.g., other loop diuretics, thiazides) because ethacrynic acid is not a sulfonamide.

IV ethacrynate sodium has been used as an adjunct to hypotensive agents in the management of hypertensive crisis, especially when accompanied by pulmonary edema.

IV ethacrynate sodium has been used in the management of hypercalcemia, alone or with sodium chloride 0.9% injection.

Has been used with mannitol in the management of ethylene glycol poisoning.

Management of bromide intoxication.

Treatment of nephrogenic diabetes insipidus that is refractory to vasopressin or chlorpropamide.

• Generic Name: clonidine
• Dosage Forms: tablet, extended release, oral suspension, extended release
• Other Brand Names: Catapres, Catapres-TTS, Duraclon, Kapvay, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3

Clonidine is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk for heart attacks. These problems may be less likely to occur if the blood pressure is controlled.

Clonidine belongs to the class of medicines called antihypertensives. It works in the brain to change some of the nerve impulses. As a result, the blood vessels relax and blood passes through them more easily, which lowers blood pressure. When the blood pressure is lowered, the amount of blood and oxygen going to the heart is increased.

This medicine will not cure your high blood pressure, but it does help control it. Therefore, you must continue to use it as directed if you expect to lower your blood pressure and keep it down. You might have to take high blood pressure medicine for the rest of your life.

Kapvay® extended-release tablets is used alone or together with other medicines to treat attention deficit hyperactivity disorder (ADHD). It works by increasing attention and decreasing restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. This medicine is used as part of a total treatment program that also includes social, educational, and psychological treatment.

This medicine is available only with your doctor's prescription.