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Ethacrynic Sodium and Ziac

Determining the interaction of Ethacrynic Sodium and Ziac and the possibility of their joint administration.

Check result:

Ethacrynic Sodium <> Ziac

Relevance: 26.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking hydroCHLOROthiazide, tell your doctor if you also use ethacrynic acid. You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium. You should contact your doctor if you have symptoms such as dizziness, dry mouth, thirst, tired feeling, muscle cramps, fast heart rate, urinating less than usual, or feeling like you might pass out. Blood pressure and kidney function should be monitored regularly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: The combination of a thiazide and loop diuretic may produce additive or synergistic effects on diuresis and excretion of electrolytes including sodium, potassium, magnesium, and chloride. Although these agents may be combined therapeutically in some patients with inadequate response to a single agent, the increased risk of dehydration, hypotension, hypokalemia, hypomagnesemia, and hyponatremia should be recognized. The exact mechanism of interaction is unclear but appears to be pharmacodynamic rather than pharmacokinetic.

MANAGEMENT: Caution is advised during concomitant use of a thiazide and loop diuretic. Dosages should be titrated slowly and carefully, and electrolytes, BUN, fluid status, blood pressure, and renal function should be monitored regularly. Patients should be advised to contact their physician if they experience signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, lethargy, muscle cramps, decreased urination, postural hypotension, and tachycardia.

References

Leary WP, Reyes AJ "Drug interactions with diuretics." S Afr Med J 65 (1984): 455-61
Brater DC, Pressley RH, Anderson SA "Mechanisms of the synergistic combination of metolazone and bumetanide." J Pharmacol Exp Ther 233 (1985): 70-4
Nakahama H, Orita Y, Yamazaki M, et al "Pharmacokinetic and pharmacodynamic interactions between furosemide and hydrochlorothiazide in nephrotic patients." Nephron 49 (1988): 223-7
Marone C, Muggli F, Lahn W, Frey FJ "Pharmacokinetic and pharmacodynamic interaction between furosemide and metolazone in man." Eur J Clin Invest 15 (1985): 253-7
Sigurd B, Olesen KH, Wennevold A "The supra-additive natriuretic effect of addition of bendroflumethiazide and bumetanide in congestive heart failure. Permutation trial tests in patients in long-term treatment with bumetanide." Am Heart J 89 (1975): 163-70
Wollam GL, Tarazi RC, Bravo EL, Dustan HP "Diuretic potency of combined hydrochlorothiazide and furosemide therapy in patients with azotemia." Am J Med 72 (1982): 929-38
Arnold WC "Efficacy of metolazone and furosemide in children with furosemide-resistant edema." Pediatrics 74 (1984): 872-5
Haller C, Salbach P, Katus H, Kubler W "Refractory oedema in congestive heart failure: a contributory role of loop diuretics?" J Intern Med 237 (1995): 211-4
Fliser D, Schroter M, Neubeck M, Ritz E "Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure." Kidney Int 46 (1994): 482-8

Ethacrynic Sodium

Generic Name: ethacrynic acid

Brand name: Edecrin, Edecrin Sodium, Sodium Edecrin

Synonyms: Ethacrynic acid, Ethacrynic Acid

What is Ethacrynic Sodium?

Ziac

Generic Name: bisoprolol / hydrochlorothiazide

Brand name: Ziac

Synonyms: n.a.

What is Ziac?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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