Ethambutol and Gaviscon

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aluminum hydroxide together with ethambutol may decrease the effects of ethambutol. Aluminum hydroxide should be avoided for at least 4 hours following ethambutol. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concurrent administration of antacids containing aluminum hydroxide may decrease the oral absorption of ethambutol. The exact mechanism of interaction has not been established. In 13 patients with tuberculosis, aluminum hydroxide (1.5 g given with a single 50 mg/kg dose of ethambutol, then 15 and 30 minutes later) decreased the mean serum concentrations and 10-hour urinary excretion of ethambutol by approximately 20% and 13%, respectively, compared to administration of ethambutol alone. Serum ethambutol levels remained significantly reduced during the first four hours postdose. There was substantial interpatient variation, with some patients demonstrating no interaction and others demonstrating increased absorption. Another study with 14 healthy subjects found that aluminum-magnesium hydroxide (30 mL given 9 hours before and concurrently with a single 25 mg/kg dose of ethambutol, then after meals and also at bedtime postdose) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ethambutol by 29% and 10%, respectively. Ethambutol time to reach Cmax was increased by 17% during antacid use.

MANAGEMENT: To minimize the potential for interaction, ethambutol labeling recommends that aluminum hydroxide-containing antacids be avoided for at least 4 hours following ethambutol administration.

Ethambutol

Generic Name: ethambutol

Brand name: Myambutol

Synonyms: n.a.

What is Ethambutol?

Gaviscon

Generic Name: aluminum hydroxide / magnesium carbonate

Brand name: Acid Gone, Gaviscon, Gaviscon Extra Relief Formula

Synonyms: n.a.

What is Gaviscon?