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Ethinyl Estradiol and Drospirenone and Frova

Determining the interaction of Ethinyl Estradiol and Drospirenone and Frova and the possibility of their joint administration.

Check result:
Ethinyl Estradiol and Drospirenone <> Frova
Relevance: 08.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The concurrent use of oral contraceptives may increase the plasma concentrations of frovatriptan. According to the manufacturer, retrospective analysis of pharmacokinetic data from females across trials indicated that the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of frovatriptan are 30% higher in oral contraceptive users compared to non-users. The mechanism of interaction has not been established, and it is not known if hormonal contraceptives delivered by other routes (intravaginal, transdermal) may similarly affect the pharmacokinetics of frovatriptan. Regardless, this interaction is unlikely to be of clinical significance.

References
  • "Product Information. Frova (frovatriptan)." Endo Laboratories LLC, Chadds Ford, PA.
Ethinyl Estradiol and Drospirenone

Generic Name: drospirenone / ethinyl estradiol

Brand name: Gianvi, Jasmiel, Loryna, Nikki, Ocella, Syeda, Vestura, Yasmin, Yaz, Zarah, Lo-Zumandimine, Zumandimine, Ocella, Yasmin 28, Yaz

Synonyms: Drospirenone and ethinyl estradiol

Frova

Generic Name: frovatriptan

Brand name: Frova

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle