Ethinyl estradiol and norelgestromin transdermal and Klonopin Wafer
Determining the interaction of Ethinyl estradiol and norelgestromin transdermal and Klonopin Wafer and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral contraceptives may prolong the half-life of certain benzodiazepines that undergo hepatic oxidative metabolism (such as diazepam and chlordiazepoxide). Other benzodiazepines also may participate in this interaction. Close observation for signs and symptoms of altered benzodiazepine effect is recommended.
- Stoehr GP, Kroboth PD, Juhl RP, Wender DB, Phillips JP, Smith RB "Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics." Clin Pharmacol Ther 36 (1984): 683-90
- Abernethy DR, Greenblatt DJ, Divoll M, Arendt R, Ochs HR, Shader RI "Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids." N Engl J Med 306 (1982): 791-2
- Patwardhan RV, Mitchell MC, Johnson RF, Schenker S "Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines." Hepatology 3 (1983): 248-53
- Scavone JM, Greenblatt DJ, Locniskar A, Shader RI "Alprazolam pharmacokinetics in women on low-dose oral contraceptives." J Clin Pharmacol 28 (1988): 454-7
Generic Name: ethinyl estradiol / norelgestromin
Brand name: Xulane, Ortho Evra
Synonyms: Ethinyl estradiol and norelgestromin (transdermal), Ethinyl Estradiol and Norelgestromin
Generic Name: clonazepam
Brand name: Klonopin Wafer, Klonopin
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ethinyl estradiol and norelgestromin transdermal-Klonopin Wafers
- Ethinyl estradiol and norelgestromin transdermal-Klor-Con
- Ethinyl estradiol and norelgestromin transdermal-Klor-Con M
- Ethinyl estradiol and norelgestromin transdermal-Klor-Con Powder
- Ethinyl estradiol and norelgestromin transdermal-Klor-Con Sprinkle
- Ethinyl estradiol and norelgestromin transdermal-Klor-Con/EF
- Klonopin Wafer-Ethinyl estradiol and norethindrone
- Klonopin Wafer-Ethinyl estradiol and norethindrone birth control
- Klonopin Wafer-Ethinyl Estradiol and Norethindrone Chewable Tabs & Ferrous Fumarate Tabs
- Klonopin Wafer-Ethinyl estradiol and norethindrone HRT
- Klonopin Wafer-Ethinyl Estradiol and Norethindrone Tablets
- Klonopin Wafer-Ethinyl estradiol and norgestimate