Ethinyl estradiol and norelgestromin transdermal and Tegaserod Maleate
Determining the interaction of Ethinyl estradiol and norelgestromin transdermal and Tegaserod Maleate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Tegaserod decreased levonorgestrel plasma concentrations by less than 10% in a clinical study with a low-dose triphasic oral contraceptive (n=45). The mechanism is unknown. There were no changes in ethinyl estradiol concentrations or in contraceptive efficacy. No action is necessary.
- Vickers AE, Zollinger M, Dannecker R, Tynes R, Heitz F, Fischer V "In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions." Drug Metab Dispos 29 (2001): 1269-76
- "Product Information. Zelnorm (tegaserod)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: ethinyl estradiol / norelgestromin
Brand name: Xulane, Ortho Evra
Synonyms: Ethinyl estradiol and norelgestromin (transdermal), Ethinyl Estradiol and Norelgestromin
Generic Name: tegaserod
Brand name: Zelnorm
Synonyms: Tegaserod
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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