Ethinyl Estradiol and Norethindrone Tablets and Thorazine (Chlorpromazine Injection)
Determining the interaction of Ethinyl Estradiol and Norethindrone Tablets and Thorazine (Chlorpromazine Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using chlorproMAZINE together with ethinyl estradiol may increase the effects of chlorproMAZINE. Contact your doctor if you experience tremor, uncontrollable movements, or excessive sedation. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: High chlorpromazine plasma concentrations and toxicity have been reported during concomitant use of an oral contraceptive. Chlorpromazine levels increased six-fold (from 134 ng/mL to 838 ng/mL) approximately one week after a patient started taking an ethinyl estradiol-norgestrel combination contraceptive, and she experienced tremors and severe dyskinesias. The mechanism is unknown but inhibition of CYP450 metabolism or effects on P-glycoprotein transport by contraceptive hormones have been suggested. Causality was not clearly determined.
MANAGEMENT: Until more information is available, monitoring for signs and symptoms of chlorpromazine toxicity when oral contraceptives are added to the regimen is recommended. Patients should be advised to notify their physician if they experience symptoms such as tremor, dyskinesias, or excessive sedation.
- Chetty M, Miller R "Oral contraceptives increase the plasma concentrations of chlorpromazine." Ther Drug Monit 23 (2001): 556-8
Generic Name: ethinyl estradiol / norethindrone
Brand name: femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon
Synonyms: Ethinyl estradiol and norethindrone (HRT), Ethinyl Estradiol and Norethindrone
Generic Name: chlorpromazine
Brand name: Thorazine, Ormazine, Thorazine Spansule
Synonyms: Thorazine (Injection), Thorazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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