Ethinyl Estradiol, Drospirenone, and Levomefolate and Novo-Cholamine Light
Determining the interaction of Ethinyl Estradiol, Drospirenone, and Levomefolate and Novo-Cholamine Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with bile-acid binding resins such as cholestyramine may decrease the plasma concentrations and therapeutic effects of estrogens and progestins. The proposed mechanism involves delaying or reducing the absorption of concomitant orally administered drugs by cholestyramine. In addition, it has also been suggested that bile-acid binding resins may interfere with the enterohepatic recycling of estrogens and therefore increase their elimination. MANAGEMENT: Estrogens and/or progestin-containing oral medications should be administered at least one hour before or four to six hours after bile-acid binding resins such as cholestyramine, colestipol, and colesevelam. Patients receiving this combination should be advised to closely follow dosing schedules to prevent loss of therapeutic effects. References "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY. Underhill KL, Rotter BA, Thompson BK, Prelusky DB, Trenholm HL "Effectiveness of cholestyramine in the detoxification of zearalenone as determined in mice." Bull Environ Contam Toxicol 54 (1995): 128-34 Arts CJM, Govers CARL, van den Berg H, Wolters MGE, van Leeuwen P, Thijssen JHH "In vitro binding of estrogens by dietary fiber and the in vivo apparent digestibility tested in pigs." J Steroid Biochem Mol Biol 38 (1991): 621-8 Cerner Multum, Inc. "Australian Product Information." O 0 Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]): Cerner Multum, Inc. "Canadian Product Information." O 0 (2015): View all 6 references
Professional:MONITOR: Coadministration with bile-acid binding resins such as cholestyramine may decrease the plasma concentrations and therapeutic effects of estrogens and progestins. The proposed mechanism involves delaying or reducing the absorption of concomitant orally administered drugs by cholestyramine. In addition, it has also been suggested that bile-acid binding resins may interfere with the enterohepatic recycling of estrogens and therefore increase their elimination.
MANAGEMENT: Estrogens and/or progestin-containing oral medications should be administered at least one hour before or four to six hours after bile-acid binding resins such as cholestyramine, colestipol, and colesevelam. Patients receiving this combination should be advised to closely follow dosing schedules to prevent loss of therapeutic effects.
- "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
- Underhill KL, Rotter BA, Thompson BK, Prelusky DB, Trenholm HL "Effectiveness of cholestyramine in the detoxification of zearalenone as determined in mice." Bull Environ Contam Toxicol 54 (1995): 128-34
- Arts CJM, Govers CARL, van den Berg H, Wolters MGE, van Leeuwen P, Thijssen JHH "In vitro binding of estrogens by dietary fiber and the in vivo apparent digestibility tested in pigs." J Steroid Biochem Mol Biol 38 (1991): 621-8
- Cerner Multum, Inc. "Australian Product Information." O 0
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
Generic Name: drospirenone / ethinyl estradiol / levomefolate calcium
Brand name: Beyaz, Safyral, Rajani, Tydemy
Synonyms: Drospirenone, ethinyl estradiol, and levomefolate
Generic Name: cholestyramine
Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: Cholestyramine, Cholestyramine Resin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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