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Ethmozine and TheoCap

Determining the interaction of Ethmozine and TheoCap and the possibility of their joint administration.

Check result:

Ethmozine <> TheoCap

Relevance: 18.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Moricizine may increase the plasma clearance of theophylline by 46% to 68% and decrease theophylline half-life by 20% to 34%. Decreased plasma theophylline levels may result. Conversely, theophylline toxicity may occur when moricizine is discontinued. The mechanism is unknown, but may be related to hepatic enzyme induction. Management consists of monitoring the patient for theophylline efficacy, checking levels if indicated, and adjusting theophylline dosage accordingly. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms.

References

Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Pieniaszek HJ Jr, Davidson AF, Benedek IH "Effect of moricizine on the pharmacokinetics of single-dose theophylline in healthy subjects." Ther Drug Monit 15 (1993): 199-203
Siddoway LA, Schwartz SL, Barbey JT, Woosley RL "Clinical pharmacokinetics of moricizine." Am J Cardiol 65 (1990): d21-5; disc. D68-71

Ethmozine

Generic Name: moricizine

Brand name:

Synonyms: n.a.

What is Ethmozine?

TheoCap

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: TheoCap (Oral)

What is TheoCap?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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