Etoposide injection and Sandimmune (Cyclosporine Injection)
Determining the interaction of Etoposide injection and Sandimmune (Cyclosporine Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using etoposide together with cycloSPORINE may increase the effects of etoposide. Contact your doctor if you experience nausea, vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: High-dose cyclosporine (concentration greater than 2,000 ng/mL) has been shown to significantly increase systemic etoposide exposure and leukopenia. The mechanism is believed to be inhibition of the multidrug transporter P-glycoprotein in normal tissues.
MANAGEMENT: In combination with high-dose cyclosporine, etoposide dosage may be reduced by 50%. Complete blood counts should be monitored.
- Bisogno G, Cowie F, Boddy A, Thomas HD, Dick G, Pinkerton CR "High-dose cyclosporin with etoposide--toxicity and pharmacokinetic interaction in children with solid tumours." Br J Cancer 77 (1998): 2304-9
- Lum BL, Kaubisch S, Yahanda AM, Adler KM, Jew L, Ehsan MN, Brophy NA, Halsey J, Gosland MP, Sikic BI "Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance." J Clin Oncol 10 (1992): 1635-42
Generic Name: etoposide
Brand name: VePesid, Etopophos, Toposar
Synonyms: Etoposide
Generic Name: cyclosporine
Brand name: Sandimmune, Gengraf, Neoral, Sandimmune
Synonyms: Sandimmune (Injection), Sandimmune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Etoposide injection-Sandimmune (Cyclosporine Oral Solution)
- Etoposide injection-Sandimmune (Cyclosporine Soft Gelatin Capsules)
- Etoposide injection-Sandimmune Oral
- Etoposide injection-Sandostatin
- Etoposide injection-Sandostatin LAR
- Etoposide injection-Sandostatin LAR Depot
- Sandimmune (Cyclosporine Injection)-Etoposide Oral, Intravenous
- Sandimmune (Cyclosporine Injection)-Etoposide phosphate
- Sandimmune (Cyclosporine Injection)-Etrafon
- Sandimmune (Cyclosporine Injection)-Etrafon Forte
- Sandimmune (Cyclosporine Injection)-Etravirine
- Sandimmune (Cyclosporine Injection)-Eucalyptamint