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Etoposide phosphate and Ifosfamide Intravenous

Determining the interaction of Etoposide phosphate and Ifosfamide Intravenous and the possibility of their joint administration.

Check result:
Etoposide phosphate <> Ifosfamide Intravenous
Relevance: 12.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using etoposide together with ifosfamide may increase the effects of etoposide. Contact your doctor if you experience severe nausea and vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data have revealed evidence of significantly decreased etoposide (VP-16) clearance in the presence of ifosfamide. The mechanism is not known, but could be ifosfamide-induced renal dysfunction and a consequent decrease in the renal clearance of etoposide.

MANAGEMENT: Although more data are needed, it is recommended that the patient be monitored for etoposide side effects during coadministration, particularly in the presence of renal dysfunction.

References
  • Crom WR, Kearns CM, Meyer WH, Rodman JH "Changes in etoposide pharmacokinetics during combination chemotherapy with ifofosfamide in Ewing sarcoma patients." Proc Annu Meet Am Assoc Cancer Res 32 (1991): a1038
Etoposide phosphate

Generic Name: etoposide

Brand name: VePesid, Etopophos, Toposar

Synonyms: Etoposide

Ifosfamide Intravenous

Generic Name: ifosfamide

Brand name: Ifex

Synonyms: Ifosfamide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle