Etravirine and Ketoconazole (Systemic)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ketoconazole together with etravirine may alter the effects of both medications. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of etravirine and itraconazole or ketoconazole may result in increased plasma concentrations of etravirine and decreased plasma concentration of the azole antifungal agent. Etravirine is a substrate as well as inducer of CYP450 3A4, while itraconazole and ketoconazole are both substrates and potent inhibitors of CYP450 3A4. Theoretically, itraconazole and ketoconazole can inhibit the metabolism of etravirine, and etravirine can induce the metabolism of the azole antifungal agents.

MANAGEMENT: Because safety data regarding increased etravirine exposures are limited, caution is advised if etravirine is prescribed in combination with itraconazole or ketoconazole. In addition, dosage adjustments may be required for the azole antifungal agent, depending on other coadministered drugs.

Etravirine

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Etravirine?

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?