Etravirine and Symfi

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using efavirenz together with etravirine, this may decrease the effects of etravirine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with efavirenz or nevirapine may significantly decrease the plasma concentrations of etravirine. The proposed mechanism is induction of etravirine metabolism via CYP450 3A4.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, the use of etravirine in combination with efavirenz or nevirapine should be avoided. The combination is also not recommended because concurrent use of two or more nonnucleoside reverse transcriptase inhibitors in an antiretroviral regimen has not demonstrated beneficial effects.

Etravirine

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Etravirine?

Symfi

Generic Name: efavirenz / lamivudine / tenofovir

Brand name: Symfi, Symfi Lo

Synonyms: n.a.

What is Symfi?