Etravirine and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using voriconazole together with etravirine can increase the blood levels or add to the side effects of either medication. Contact your doctor if you experience increased side effects or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of etravirine and voriconazole may result in increased plasma concentrations of both drugs. Etravirine is a substrate of CYP450 2C19, 2C9 and 3A4 as well as an inhibitor of CYP450 2C19 and 2C9, while voriconazole is a substrate of CYP450 2C19 and inhibitor of CYP450 2C19, 2C9 and 3A4. Theoretically, etravirine can inhibit the metabolism of voriconazole via CYP450 2C19, and voriconazole can inhibit the metabolism of etravirine via CYP450 2C19, 2C9 and 3A4.

MANAGEMENT: Because safety data regarding increased etravirine exposures are limited, caution is advised if etravirine is prescribed in combination with voriconazole. Dosage adjustments may be required for one or both drugs if undue adverse effects occur.

Etravirine

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Etravirine?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?