Etravirine and ZoDex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using etravirine together with dexamethasone may reduce the blood levels and effects of both medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your conditions worsen during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of etravirine with a drug that is both a substrate as well as inducer of CYP450 3A4 may result in decreased plasma concentrations of both drugs. Etravirine itself is also a substrate and inducer of CYP450 3A4. Theoretically, metabolism of etravirine and the coadministered drug may be mutually induced when used in combination.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is advised if etravirine is prescribed in combination with a drug that is an inducer of CYP450 3A4. Close clinical and laboratory monitoring of antiretroviral response is recommended. In addition, dosage adjustments may be required for the coadministered drug if it is also a substrate of CYP450 3A4.

Etravirine

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Etravirine?

ZoDex

Generic Name: dexamethasone

Brand name: ZoDex, Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, Zonacort

Synonyms: n.a.

What is ZoDex?