Evening Primrose and Osmolex ER
Determining the interaction of Evening Primrose and Osmolex ER and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some clinicians have suggested that evening primrose and borage oil, both of which contain the omega-6 fatty acid gamma linolenic acid (GLA), may lower the seizure threshold and increase the risk of seizures during co-administration with other epileptogenic agents. However, data regarding the effect of gamma linolenic acid on seizure threshold are conflicting and limited.
- N. A. Michael Eskin "Borage and evening primrose oil." European Journal of Lipid Science and Technology 110 (2008): 1
- Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
- Asadi-Samani M, Bahmani M, Rafieian-Kopaei M "The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review." Asian Pac J Trop Med 7S1 (2014): S22-8
- Therapeutic Research Faculty "Natural Medicines Comprehensive Database. Available from: URL: http://www.naturaldatabase.com." ([1995-2008...]):
Generic Name: evening primrose
Brand name: Primrose Oil, Evening Primrose Oil
Synonyms: Evening Primrose Oil
Generic Name: amantadine
Brand name: Gocovri, Osmolex ER, Symmetrel
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Evening Primrose-OsmoPrep
- Evening Primrose-OsmoPrep Oral
- Evening Primrose-Ospemifene
- Evening Primrose-Osphena
- Evening Primrose-Osteo Bi-Flex
- Evening Primrose-Osteo Bi-Flex Advanced MSM
- Osmolex ER-Evening Primrose Oil
- Osmolex ER-Evenity
- Osmolex ER-Evenity Injection
- Osmolex ER-Everolimus
- Osmolex ER-Everolimus Tablets (Afinitor)
- Osmolex ER-Everolimus Tablets (Zortress)