Evening Primrose Oil and Guaifenesin and Codeine
Determining the interaction of Evening Primrose Oil and Guaifenesin and Codeine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some clinicians have suggested that evening primrose and borage oil, both of which contain the omega-6 fatty acid gamma linolenic acid (GLA), may lower the seizure threshold and increase the risk of seizures during co-administration with other epileptogenic agents. However, data regarding the effect of gamma linolenic acid on seizure threshold are conflicting and limited.
- N. A. Michael Eskin "Borage and evening primrose oil." European Journal of Lipid Science and Technology 110 (2008): 1
- Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11
- Asadi-Samani M, Bahmani M, Rafieian-Kopaei M "The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review." Asian Pac J Trop Med 7S1 (2014): S22-8
- Therapeutic Research Faculty "Natural Medicines Comprehensive Database. Available from: URL: http://www.naturaldatabase.com." ([1995-2008...]):
Generic Name: evening primrose
Brand name: Primrose Oil, Evening Primrose Oil
Synonyms: Evening Primrose
Generic Name: codeine / guaifenesin
Brand name: Allfen CD, Cheracol with Codeine, Cheratussin AC, Codar GF, Duraganidin NR, Guaiatussin AC, Iophen-C NR, Mar-cof CG, M-Clear, Mytussin AC, Relcof C, Guaifenesin AC Liquid, Iophen C-NR, Mar-cof CG, Ninjacof-XG, Virtussin A/C
Synonyms: Codeine and guaifenesin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Evening Primrose Oil-Guaifenesin and Dextromethorphan Capsules and Tablets
- Evening Primrose Oil-Guaifenesin and Dextromethorphan Extended-Release Tablets
- Evening Primrose Oil-Guaifenesin and Dextromethorphan Granule Packets
- Evening Primrose Oil-Guaifenesin and Dextromethorphan Liquid
- Evening Primrose Oil-Guaifenesin and hydrocodone
- Evening Primrose Oil-Guaifenesin and phenylephrine
- Guaifenesin and Codeine-Evenity
- Guaifenesin and Codeine-Evenity Injection
- Guaifenesin and Codeine-Everolimus
- Guaifenesin and Codeine-Everolimus Tablets (Afinitor)
- Guaifenesin and Codeine-Everolimus Tablets (Zortress)
- Guaifenesin and Codeine-Everolimus Tablets For Oral Suspension