Everolimus and Lapatinib Ditosylate
Determining the interaction of Everolimus and Lapatinib Ditosylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Lapatinib may increase the blood levels of everolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience new or worsening side effects of everolimus such as mouth ulcers, fever, infection, shortness of breath, diarrhea, dizziness, paleness, fainting, and/or unusual bleeding or bruising while taking these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 3A4 and/or P-glycoprotein may increase the blood concentrations of everolimus following oral administration. Everolimus is a substrate of both the CYP450 3A4 isoenzyme and P-glycoprotein drug efflux transporter, thus their inhibition in the intestine can enhance the absorption of everolimus.
MANAGEMENT: The possibility of prolonged and/or increased pharmacologic effects of everolimus therapy should be considered during coadministration with CYP450 3A4 and/or P-glycoprotein inhibitors, including adverse effects such as pneumonitis, stomatitis, infection, dyspnea, diarrhea, anemia, leucopenia, thrombocytopenia, hyperglycemia, and hyperlipidemia. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy.
- "Product Information. Afinitor (everolimus)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: everolimus
Brand name: Zortress, Afinitor, Afinitor Disperz
Synonyms: n.a.
Generic Name: lapatinib
Brand name: Tykerb
Synonyms: Lapatinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Everolimus-Lariam
- Everolimus-Larin 1.5/30
- Everolimus-Larin 1/20
- Everolimus-Larin 24 Fe
- Everolimus-Larin Fe 1.5/30
- Everolimus-Larin Fe 1/20
- Lapatinib Ditosylate-Everolimus Tablets (Afinitor)
- Lapatinib Ditosylate-Everolimus Tablets (Zortress)
- Lapatinib Ditosylate-Everolimus Tablets For Oral Suspension
- Lapatinib Ditosylate-Evista
- Lapatinib Ditosylate-Evoclin
- Lapatinib Ditosylate-Evoclin Topical