Evoxac and Pazopanib
Determining the interaction of Evoxac and Pazopanib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PAZOPanib may increase the blood levels of cevimeline. This can increase side effects such as nausea, vomiting, diarrhea, sweating, drooling, increased urination, blurred vision, confusion, tremor, heart palpitations, and irregular heartbeat. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of cevimeline, which is metabolized by these isoenzymes.
MANAGEMENT: Dosage adjustments and clinical monitoring may be appropriate whenever a CYP450 2D6 and/or 3A4 inhibitor is added to or withdrawn from therapy. Patients should be advised to notify their physician if they experience excessive adverse cholinergic effects of cevimeline such as nausea, vomiting, diarrhea, sweating, salivation, urinary frequency, visual disturbance, confusion, tremor, palpitations, or irregular heartbeat.
- "Product Information. Evoxac (cevimeline)" Daiichi Pharmaceuticals, Fort lee, NJ.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Evoxac-Pazopanib Hydrochloride
- Evoxac-PB Hyos Elixir
- Evoxac-PCE
- Evoxac-PCE Dispertab
- Evoxac-PCM-LA
- Evoxac-Pedia Care Multi-Symptom Cold
- Pazopanib-Evzio
- Pazopanib-Ex-Lax
- Pazopanib-Ex-Lax Chocolated
- Pazopanib-Ex-Lax Maximum Relief Formula
- Pazopanib-Ex-Lax Milk of Magnesia
- Pazopanib-Ex-Lax Regular Strength Pills