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Ex-Lax Milk of Magnesia and Tolazamide

Determining the interaction of Ex-Lax Milk of Magnesia and Tolazamide and the possibility of their joint administration.

Check result:

Ex-Lax Milk of Magnesia <> Tolazamide

Relevance: 27.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using magnesium hydroxide together with TOLAZamide can increase the effects of TOLAZamide. TOLAZamide should be administered at least two hours before or after magnesium hydroxide. You should be advised to regularly monitor your blood sugar and counseled on how to recognize and treat hypoglycemia (low blood sugar), which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. You may need a dose adjustment or blood sugar checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Some antacids may significantly increase the absorption rate and in some cases the extent of absorption of oral sulfonylureas. The hypoglycemic effects of these agents may be altered.

MANAGEMENT: Sulfonylureas should be administered at least two hours before or after antacids. Patients should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs.

References

"Product Information. Diabeta (glyburide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
"Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY.
Kivisto KT, Neuvonen PJ "Enhancement of absorption and effect of glipizide by magnesium hydroxide." Clin Pharmacol Ther 49 (1991): 39-43
Kivisto KT, Neuvonen PJ "Effect of magnesium hydroxide on the absorption and efficacy of tolbutamide and chlorpropamide." Eur J Clin Pharmacol 42 (1992): 675-80
Kolterman OG "Glyburide in non-insulin-dependent diabetes: an update." Clin Ther 14 (1992): 196-213
Prendergast BD "Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents." Clin Pharm 3 (1984): 473-85
"Product Information. Micronase (glyburide)." Pharmacia and Upjohn, Kalamazoo, MI.

Ex-Lax Milk of Magnesia

Generic Name: magnesium hydroxide

Brand name: Ex-Lax Milk of Magnesia, Milk of Magnesia, Pedia-Lax Chewable, Phillips Milk of Magnesia, Dulcolax Milk of Magnesia, Concentrated Phillips Milk of Magnesia

Synonyms: n.a.

What is Ex-Lax Milk of Magnesia?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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