Excedrin Back & Body and Lithium ER
Determining the interaction of Excedrin Back & Body and Lithium ER and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Most studies have shown that aspirin and other salicylates do not significantly affect the serum concentrations of lithium. However, one study reported a 22% reduction in lithium clearance in six healthy female subjects given intravenous sodium salicylate, and another study reported a 32% increase in mean serum lithium level in a healthy subject given aspirin for 5 days. In general, no particular precaution should be necessary when lithium is coadministered with salicylates.
- Reimann IW, Diener U, Frolich JC "Indomethacin but not aspirin increases plasma lithium ion levels." Arch Gen Psychiatry 40 (1983): 283-6
- Phelan KM, Mosholder AD, Lu S "Lithium interaction with the cyclooxygenase 2 inhibitors rofecoxib and celecoxib and other nonsteroidal anti-inflammatory drugs." J Clin Psychiatry 64 (2003): 1328-34
- Johnson AG, Nguyen TV, Day RO "Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis." Ann Intern Med 121 (1994): 289-300
- Ragheb M "The clinical significance of lithium-nonsteroidal anti-inflammatory drug interactions." J Clin Psychopharmacol 10 (1990): 350-4
Generic Name: acetaminophen / aspirin
Brand name: Excedrin Back & Body
Synonyms: n.a.
Generic Name: lithium
Brand name: Lithobid, Eskalith, Lithonate, Lithotabs, Eskalith-CR
Synonyms: Lithium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Excedrin Back & Body-Lithium Oral Solution
- Excedrin Back & Body-Lithium Salts
- Excedrin Back & Body-Lithium Syrup and Oral Solution
- Excedrin Back & Body-Lithobid
- Excedrin Back & Body-Lithostat
- Excedrin Back & Body-Little Noses Decongestant
- Lithium ER-Excedrin Mild Headache
- Lithium ER-Excedrin PM
- Lithium ER-Excedrin Quick Tab Peppermint
- Lithium ER-Excedrin Quick Tab Spearmint
- Lithium ER-Excedrin Sinus Headache Caplet
- Lithium ER-Excedrin Tension Headache