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Excedrin PM and Reglan (Metoclopramide Injection Solution)

Determining the interaction of Excedrin PM and Reglan (Metoclopramide Injection Solution) and the possibility of their joint administration.

Check result:

Excedrin PM <> Reglan (Metoclopramide Injection Solution)

Relevance: 24.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

DiphenhydrAMINE may reduce the effects of metoclopramide. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

Professional:

GENERALLY AVOID: Anticholinergic agents and other agents with significant anticholinergic activity (e.g., clozapine, class IA antiarrhythmics especially disopyramide) may antagonize the pharmacologic effects of gastrointestinal prokinetic agents. Gastrokinetic drugs such as domperidone and metoclopramide increase gastrointestinal motility by blocking peripheral dopamine receptors. Anticholinergic agents could negate this action.

MANAGEMENT: Concomitant use of gastrointestinal prokinetic agents with anticholinergic agents should be avoided, if possible.

References

"Product Information. Reglan (metoclopramide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Motilium (domperidone)." Janssen-Ortho Inc, Toronto, ON.

Excedrin PM

Generic Name: acetaminophen / diphenhydramine

Brand name: Aceta-Gesic, Coricidin Night Time Cold Relief, Excedrin PM, Headache Relief PM, Legatrin PM, Mapap PM, Midol PM, Night Time Pain, Pain Relief PM Extra Strength, Percogesic Extra Strength, Tylenol Cold Relief Nighttime, Tylenol PM, Tylenol Sore Throat Nighttime, Unisom with Pain Relief, Tylenol Extra Strength PM, Bayer Select Max Strength Night Time Pain, Genapap PM, Excedrin PM Caplet, Sominex Pain Relief Formula, Tylenol Severe Allergy Caplet, Anacin PM. Aspirin Free, Tylenol Extra Strength PM Vanilla, Tylenol Cold Relief Caplet, Tylenol Cold Relief Nighttime Caplet, Tylenol Extra Strength PM Rapid Release Gelcaps, Excedrin PM Express, Percogesic Original Strength, Tylenol Cold Relief, Tylenol Severe Allergy

Synonyms: n.a.

What is Excedrin PM?

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: Reglan

What is Reglan (Metoclopramide Injection Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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