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Excedrin Tension Headache and Hycamtin

Determining the interaction of Excedrin Tension Headache and Hycamtin and the possibility of their joint administration.

Check result:

Excedrin Tension Headache <> Hycamtin

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The cytotoxic and cytostatic activity of topotecan may be diminished in the presence of caffeine. The mechanism is probably formation of complexes between caffeine and topotecan which result in reducing the effective concentration of the free form of topotecan. The clinical implications of this interaction are unknown.

References

Traganos F, Kapuscinski J, Gong J, Ardelt B, Darzynkiewicz RJ, Darzynkiewicz Z "Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells." Cancer Res 53 (1993): 4613-8

Excedrin Tension Headache

Generic Name: acetaminophen / caffeine

Brand name: Excedrin Mild Headache, Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra, Excedrin Tension Headache Express

Synonyms: n.a.

What is Excedrin Tension Headache?

Hycamtin

Generic Name: topotecan

Brand name: Hycamtin

Synonyms: Hycamtin (oral/injection)

What is Hycamtin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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