Excedrin Tension Headache Geltab and Pitolisant Hydrochloride
Determining the interaction of Excedrin Tension Headache Geltab and Pitolisant Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with pitolisant may reduce plasma concentrations of substrates of CYP450 2C, P-glycoprotein (P-gp), and uridine diphosphate glucuronosyltransferases (UGTs). Based on in vitro data, pitolisant and its main metabolites may induce CYP450 2C, P-gp, and UGTs. Clinical data are not available. MANAGEMENT: Caution is recommended if pitolisant is used in combination with substrates of CYP450 2C, P-gp, and/or UGTs. Clinical and laboratory monitoring may be appropriate for some drugs whenever pitolisant is added to or withdrawn from therapy. References Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
Professional:MONITOR: Coadministration with pitolisant may reduce plasma concentrations of substrates of CYP450 2C, P-glycoprotein (P-gp), and uridine diphosphate glucuronosyltransferases (UGTs). Based on in vitro data, pitolisant and its main metabolites may induce CYP450 2C, P-gp, and UGTs. Clinical data are not available.
MANAGEMENT: Caution is recommended if pitolisant is used in combination with substrates of CYP450 2C, P-gp, and/or UGTs. Clinical and laboratory monitoring may be appropriate for some drugs whenever pitolisant is added to or withdrawn from therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Wakix (pitolisant)." Harmony Biosciences, LLC, Plymouth Meeting, PA.
Generic Name: acetaminophen / caffeine
Brand name: Excedrin Mild Headache, Excedrin Quick Tab Peppermint, Excedrin Quick Tab Spearmint, Excedrin Tension Headache, Excedrin Tension Headache Caplet, Excedrin Tension Headache Express Gels, Excedrin Tension Headache Geltab, Valorin Extra, Excedrin Tension Headache Express
Synonyms: Excedrin Tension Headache
Generic Name: pitolisant
Brand name: Wakix
Synonyms: Pitolisant
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Excedrin Tension Headache Geltab-Pitressin
- Excedrin Tension Headache Geltab-Pitressin Injection
- Excedrin Tension Headache Geltab-Pitressin Synthetic
- Excedrin Tension Headache Geltab-Placidyl
- Excedrin Tension Headache Geltab-Plan B
- Excedrin Tension Headache Geltab-Plan B One-Step
- Pitolisant Hydrochloride-ExeClear
- Pitolisant Hydrochloride-ExeClear-C
- Pitolisant Hydrochloride-ExeCof XP
- Pitolisant Hydrochloride-Exefen IR Tablets
- Pitolisant Hydrochloride-Exelon
- Pitolisant Hydrochloride-Exelon (Rivastigmine Capsules)