Exelon and Pyridoxine Hydrochloride

• Generic Name: rivastigmine
• Dosage Forms: capsules and oral solution
• Other Brand Names: Exelon

Exelon (rivastigmine) improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical that is important for the processes of memory, thinking, and reasoning. People with dementia usually have lower levels of this chemical.

Exelon is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease.

Exelon is not a cure for Alzheimer's or Parkinson's disease.

The use of Exelon in in patients under 18 years of age is not recommended.

• Generic Name: pyridoxine
• Dosage Forms: n.a.
• Other Brand Names: Vitamin B6, Vitelle Nestrex, Pyridoxal 5'-Phosphate

Treatment of vitamin B6 deficiency.

Adequate intake needed to prevent vitamin B6 deficiency.

Adequate intake of pyridoxine can be accomplished through consumption of fortified ready-to-eat cereals; meals containing substantial portions of meat, fish, or poultry; white potatoes and other starchy vegetable; and noncitrus fruits.

Recommended Dietary Allowance (RDA) in adults based on a plasma pyridoxal phosphate concentration of 5 ng/mL.

Adequate intake (AI) established for infants ≤6 months of age based on observed mean vitamin B6 intake of infants fed principally human milk; AI for infants 7–12 months of age based on AI for younger infants and data in adults.

RDA for children 1–18 years of age based on data in adults.

Treatment of pyridoxine-dependent seizures.

Xanthurenic aciduria, cystathioninuria, and homocystinuria resulting from genetic abnormalities may respond to high doses of pyridoxine.

Prevent or treat neuropathy in patients receiving isoniazid. Pyridoxine prophylaxis recommended in isoniazid-treated individuals with nutritional deficiency (e.g., meat and milk-deficient diet), diabetes mellitus, HIV infection, renal failure, alcoholism, and in exclusively breast-fed infants, pregnant women, and lactating women.

Also has been used to prevent or treat neurotoxic adverse effects (e.g., peripheral neuropathy) associated with ethionamide or capecitabine.

Adjunct for treatment of acute toxicity resulting from isoniazid overdosage.

Adjunct for treatment of acute toxicity caused by mushrooms of the genus Gyromitra. Used to correct marked neurologic effects (e.g., seizures, coma) induced by methylhydrazine (produced by hydrolysis of the toxins in these mushrooms).