Exelon (Rivastigmine Capsules) and Metoprolol and Hydrochlorothiazide Tablets
Determining the interaction of Exelon (Rivastigmine Capsules) and Metoprolol and Hydrochlorothiazide Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using metoprolol and hydroCHLOROthiazide together may lower your blood pressure and slow your heart rate. This can cause dizziness, or feeling like you might pass out, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Although they are often combined in clinical practice, diuretics and beta-blockers may increase the risk of hyperglycemia and hypertriglyceridemia in some patients, especially in patients with diabetes or latent diabetes. In addition, the risk of QT interval prolongation and arrhythmias (e.g. torsades de pointes) due to sotalol may be increased by potassium-depleting diuretics.
MANAGEMENT: Monitoring of serum potassium levels, blood pressure, and blood glucose is recommended during coadministration. Patients should be advised to seek medical assistance if they experience dizziness, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control.
- Dean S, Kendall MJ, Potter S, Thompson MH, Jackson DA "Nadolol in combination with indapamide and xipamide in resistant hypertensives." Eur J Clin Pharmacol 28 (1985): 29-33
- Dornhorst A, Powell SH, Pensky J "Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion." Lancet 1 (1985): 123-6
- "Product Information. Lozol (indapamide)." Rhone-Poulenc Rorer, Collegeville, PA.
- Marcy TR, Ripley TL "Aldosterone antagonists in the treatment of heart failure." Am J Health Syst Pharm 63 (2006): 49-58
- Roux A, Le Liboux A, Delhotal B, Gaillot J, Flouvat B "Pharmacokinetics in man of acebutolol and hydrochlorothiazide as single agents and in combination." Eur J Clin Pharmacol 24 (1983): 801-6
Generic Name: rivastigmine
Brand name: Exelon
Synonyms: Exelon
Generic Name: hydrochlorothiazide / metoprolol
Brand name: Dutoprol, Lopressor HCT
Synonyms: Hydrochlorothiazide and metoprolol, Metoprolol and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Exelon (Rivastigmine Capsules)-Metoprolol Extended-Release Capsules
- Exelon (Rivastigmine Capsules)-Metoprolol Extended-Release Tablets
- Exelon (Rivastigmine Capsules)-Metoprolol Injection
- Exelon (Rivastigmine Capsules)-Metoprolol Intravenous
- Exelon (Rivastigmine Capsules)-Metoprolol Succinate
- Exelon (Rivastigmine Capsules)-Metoprolol Succinate ER Capsules
- Metoprolol and Hydrochlorothiazide Tablets-Exelon (Rivastigmine Oral Solution)
- Metoprolol and Hydrochlorothiazide Tablets-Exelon (Rivastigmine Patch)
- Metoprolol and Hydrochlorothiazide Tablets-Exelon Patch
- Metoprolol and Hydrochlorothiazide Tablets-Exelon Transdermal
- Metoprolol and Hydrochlorothiazide Tablets-Exemestane
- Metoprolol and Hydrochlorothiazide Tablets-Exemestane Tablets