Exemestane Tablets and Nutropin AQ
Determining the interaction of Exemestane Tablets and Nutropin AQ and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Somatropin may reduce the blood levels and effects of exemestane. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of exemestane, which is primarily metabolized by the isoenzyme. In 10 healthy postmenopausal volunteers, administration of exemestane (25 mg single dose) following pretreatment with the potent inducer rifampin (600 mg daily for 14 days) resulted in a 41% decrease in exemestane peak plasma concentration (Cmax) and a 54% decrease in exemestane systemic exposure (AUC).
MANAGEMENT: The manufacturer recommends increasing the dosage of exemestane to 50 mg once daily when used with potent CYP450 3A4 inducers such as carbamazepine, enzalutamide, lumacaftor, mitotane, phenobarbital, phenytoin, primidone (partially metabolized to phenobarbital), rifamycins, and St. John's wort. However, it has also been suggested that suppression of estrogen levels is not affected by the interaction, thus dosage adjustment of exemestane is not required. The extent to which other, less potent CYP450 3A4 inducers may interact with exemestane is unknown. Caution is advised if they are used with exemestane.
- "Product Information. Aromasin (exemestane)" Pharmacia & Upjohn, Kalamazoo, MI.
Generic Name: exemestane
Brand name: Aromasin
Synonyms: Exemestane
Generic Name: somatropin
Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit
Synonyms: Nutropin AQ NuSpin 10
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Exemestane Tablets-Nutropin AQ NuSpin 10
- Exemestane Tablets-Nutropin AQ NuSpin 5
- Exemestane Tablets-Nutropin AQ Pen
- Exemestane Tablets-Nutropin AQ Pen 10 Cartridge
- Exemestane Tablets-Nutropin Aq Subcutaneous, Injection
- Exemestane Tablets-Nutropin Depot
- Nutropin AQ-Exenatide
- Nutropin AQ-Exenatide extended release
- Nutropin AQ-Exenatide Extended-Release Injection (Bydureon BCise)
- Nutropin AQ-Exenatide Extended-Release Injection (Bydureon) (Pens)
- Nutropin AQ-Exenatide Extended-Release Injection (Bydureon) (Trays)
- Nutropin AQ-Exenatide Injection (Byetta)