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Ezallor Sprinkle and Zykadia

Determining the interaction of Ezallor Sprinkle and Zykadia and the possibility of their joint administration.

Check result:

Ezallor Sprinkle <> Zykadia

Relevance: 07.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ceritinib may increase the blood levels and effects of rosuvastatin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ceritinib may increase the plasma concentrations and the risk of adverse effects of orally administered drugs that are substrates of the intestinal P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) transporters, such as dabigatran, rosuvastatin, sulfasalazine, and topotecan. The proposed mechanism, based on in vitro data, is decreased clearance due to ceritinib-mediated inhibition of intestinal P-gp and/or BCRP efflux transport proteins.

MANAGEMENT: Caution is advised if ceritinib is used concomitantly with drugs that are substrates of the intestinal P-gp and/or BCRP transport proteins, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever ceritinib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Ezallor Sprinkle

Generic Name: rosuvastatin

Brand name: Crestor, Ezallor Sprinkle

Synonyms: n.a.

What is Ezallor Sprinkle?

Zykadia

Generic Name: ceritinib

Brand name: Zykadia

Synonyms: n.a.

What is Zykadia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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