EZChar and Mycophenolate Suspension

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Charcoal may interfere with the absorption of mycophenolate mofetil, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with bile acid sequestrants or activated charcoal may decrease the bioavailability of mycophenolic acid. In 12 healthy volunteers, pretreatment with cholestyramine (4 g three times a day for 4 days) decreased the systemic exposure (AUC) of mycophenolic acid (from mycophenolate mofetil 1.5 g single dose) by 40% compared to administration of mycophenolate mofetil alone. The proposed mechanism is interruption of enterohepatic recirculation due to binding of recirculating mycophenolic acid glucuronide (a product of the first-pass metabolism of mycophenolic acid) with cholestyramine in the intestine. Some degree of enterohepatic recirculation is also anticipated following intravenous administration of mycophenolate mofetil, thus the interaction is not limited to the oral route.

MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant blood levels, mycophenolic acid products should not be administered with cholestyramine or other agents that may interfere with enterohepatic recirculation or bind bile acids (e.g., activated charcoal).

EZChar

Generic Name: charcoal

Brand name: Actidose-Aqua, Activated Charcoal, Charcoal Plus DS, EZChar, Insta-Char, Liqui-Char, Optimum Charcoal, Liqui-Char with Sorbitol, Charcocaps, Activated Charcoal with Sorbitol, Charcoaid 2000, Charcoaid-G, Char-Flo with Sorbitol, Charcoaid, Charcodote, Char-Flo Aqueous Base, Actidose-Aqua Advance, JL. Bragg's Medicinal Charcoal, Medicoal, Karbons, Carbomix, Carbosorb X, Charcotabs, Healthstream Activated Charcoal, Charcotrace, Chem Mart Nasal Decongestant Capsule, Pharmacia Carbosorb, Norit, Eucarbon, Active Carbon

Synonyms: n.a.

What is EZChar?

Mycophenolate Suspension

Generic Name: mycophenolate mofetil

Brand name: Cellcept, Myfortic, MMF

Synonyms: Mycophenolate mofetil (oral/injection), Mycophenolate

What is Mycophenolate Suspension?