Ezetimibe and Questran Light
Determining the interaction of Ezetimibe and Questran Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cholestyramine together with ezetimibe may decrease the effects of ezetimibe. Ezetimibe should be administered at least 2 hours before or 4 hours after cholestyramine. Contact your doctor if your condition worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: In a study of 40 healthy hypercholesterolemic adults, concomitant administration of cholestyramine (4 g twice daily) decreased the mean area under the plasma concentration-time curve (AUC) of total ezetimibe by approximately 55%. The incremental LDL cholesterol reduction expected with the addition of ezetimibe to cholestyramine or other bile acid sequestrants may be diminished by this interaction.
MANAGEMENT: Ezetimibe should be administered at least 2 hours before or 4 hours after the bile acid sequestrant.
- "Product Information. Zetia (ezetimibe)." Schering-Plough Corporation, Kenilworth, NJ.
Generic Name: cholestyramine
Brand name: Prevalite, Questran, Questran Light, Cholestyramine Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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