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FaBB and Welchol

Determining the interaction of FaBB and Welchol and the possibility of their joint administration.

Check result:

FaBB <> Welchol

Relevance: 10.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using colesevelam together with multivitamin may decrease the effects of multivitamin. Multivitamin should be administered at least 4 hours before colesevelam. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).

MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.

References

Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.

FaBB

Generic Name: multivitamin

Brand name: Airavite, Av-VITE FB, CenFol, FaBB, Folbee, GNP Antibiotic Plus Pramoxine, Multi Antibiotic Plus, Neosporin Plus Pain Relief MS, RA Antibiotic Plus, SM Antibiotic Plus Pain Relief, TGT First Aid Antibiotic, TH Antibiotic + Pain Relief, BProtected Pedia Poly-Vite, PediaVit, Polyvitamin OR SOLN, Natrol SAMe, Protegra, Vicon Forte, Stress-600, Thera-Tabs, AquADEKs, Pedia Tri-Vite Drops, Tri-Vita, Vitamax Pediatric

Synonyms: FaBB Tablets

What is FaBB?

Welchol

Generic Name: colesevelam

Brand name: Welchol, Colesevelam Hydrochloride

Synonyms: n.a.

What is Welchol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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