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Factor IX Complex (Human) [(Factors II, IX, X)] and Trasylol

Determining the interaction of Factor IX Complex (Human) [(Factors II, IX, X)] and Trasylol and the possibility of their joint administration.

Check result:

Factor IX Complex (Human) [(Factors II, IX, X)] <> Trasylol

Relevance: 04.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using aprotinin together with factor IX complex may increase the risk of blood clots, which can lead to serious complications such as stroke, pulmonary embolism (blockage of pulmonary artery), heart attack, heart failure, collapse, and kidney failure. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need to wait a certain amount of time after using one medication before using the other. You should seek immediate medical attention if you experience potential signs and symptoms of blood clots such as chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

Professional:

GENERALLY AVOID: Due to additive or synergistic pharmacodynamic effects, the risk of thrombosis may be increased when antifibrinolytic agents (e.g., aminocaproic acid, aprotinin, tranexamic acid) are coadministered with other hemostatic agents such as anti-inhibitor coagulant complex, factor IX complex, or prothrombin complex.

MANAGEMENT: Concomitant administration of antifibrinolytic agents with other hemostatic agents should generally be avoided. Consult the manufacturer's product labeling for recommended dosing intervals between products.

References

"Product Information. LYSTEDA (tranexamic acid)." Xanodyne Pharmaceuticals Inc, Newport, KY.
"Product Information. Amicar (aminocaproic acid)." Immunex Corporation, Seattle, WA.
"Product Information. Cyklokapron (tranexamic acid)." Pharmacia and Upjohn, Kalamazoo, MI.

Factor IX Complex (Human) [(Factors II, IX, X)]

Generic Name: factor ix complex

Brand name: Bebulin, Bebulin VH, Profilnine SD, Konyne 80, Proplex T, Profilnine, Mononine, Alphanine SD, Alphanine SD

Synonyms: Factor IX complex

What is Factor IX Complex (Human) [(Factors II, IX, X)]?

Trasylol

Generic Name: aprotinin

Brand name:

Synonyms: n.a.

What is Trasylol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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