Famotidine and ibuprofen and Valproic acid
Determining the interaction of Famotidine and ibuprofen and Valproic acid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.
- Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7
Generic Name: famotidine / ibuprofen
Brand name: Duexis
Synonyms: Ibuprofen and Famotidine
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproic Acid and Derivatives
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Famotidine and ibuprofen-Valproic Acid and Derivatives
- Famotidine and ibuprofen-Valproic Acid Capsules
- Famotidine and ibuprofen-Valproic Acid Liquid
- Famotidine and ibuprofen-Valproic Acid Oral Solution
- Famotidine and ibuprofen-Valproic Acid Syrup
- Famotidine and ibuprofen-Valrubicin
- Valproic acid-Famotidine Chewable Tablets
- Valproic acid-Famotidine Injection
- Valproic acid-Famotidine Injection Solution
- Valproic acid-Famotidine Oral Suspension
- Valproic acid-Famotidine Tablets
- Valproic acid-Famotidine, Calcium Carbonate, and Magnesium Hydroxide