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Farydak and Histex

Determining the interaction of Farydak and Histex and the possibility of their joint administration.

Check result:

Farydak <> Histex

Relevance: 13.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Panobinostat may increase the blood levels and effects of chlorpheniramine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with panobinostat may increase the plasma concentrations of drugs that are substrates of CYP450 2D6. The mechanism is decreased clearance due to inhibition of CYP450 2D6 activity by panobinostat. When a single 60 mg dose of dextromethorphan, a CYP450 2D6 probe substrate, was coadministered with panobinostat (20 mg once per day on days 3, 5, and 8) in 14 patients with advanced cancer, dextromethorphan peak plasma concentration (Cmax) increased by 20% to 200% (median 80%) and systemic exposure (AUC) increased by 20% to 130% (median 60%) compared to administration of dextromethorphan alone.

MANAGEMENT: Given the high interpatient variability with respect to magnitude of interaction, concomitant use of panobinostat with sensitive CYP450 2D6 substrates (e.g., atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine) or CYP450 2D6 substrates that have a narrow therapeutic index (e.g., pimozide, thioridazine) should generally be avoided. Caution is advised when panobinostat is used with other drugs that are metabolized by CYP450 2D6.

References

"Product Information. Farydak (panobinostat)." Novartis Pharmaceuticals, East Hanover, NJ.

Farydak

Generic Name: panobinostat

Brand name: Farydak

Synonyms: n.a.

What is Farydak?

Histex

Generic Name: chlorpheniramine / pseudoephedrine

Brand name: Allerest Maximum Strength, Dicel, LoHist-D, SudoGest Sinus & Allergy, Triaminic Cold and Allergy, Clorfed, Histalet, Fedahist, Tanafed, Novafed A, Chlorafed HS. Timecelles, Codimal-LA, Kronofed-A-Jr, Rescon, Rescon JR, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Deconamine SR, Pseudochlor, Cophene No. 2, Anaplex, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Deconamine, Clorfed II, Curaler, Sudafed Plus, Chlorafed, Histafed LA, Chlor Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Ryna Liquid, Genaphed Plus, Dayquil Allergy, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Histex, Triaminic Softchew Cold and Allergy, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Biohist LA, Dynahist-ER Pediatric, Pediacare Cold and Allergy, CP-Tannic, Durafed, Histade, Duotan, Mintex, QDall, Suclor, Sudafed Sinus/Allergy, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, Triaminic Softchews Allergy Nose & Congestion, Duratuss DA, Neutrahist Drops, AccuHist Drops, Sudogest Cold & Allergy, Dicel Chewables, PediaCare Cold/Allergy

Synonyms: Chlorpheniramine and pseudoephedrine, Chlorphen Mal, Pseudoeph HCl

What is Histex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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